Cancer Therapy: Preclinical b-Mannosylceramide Activates Type I Natural Killer T Cells to Induce Tumor Immunity without Inducing Long-Term Functional Anergy
نویسندگان
چکیده
Purpose:Most studies characterizing antitumor properties of invariant natural killer T (iNKT) cells have used the agonist, a-galactosylceramide (a-GalCer). However, a-GalCer induces strong, long-lasting anergy of iNKT cells, which could be a major detriment for clinical therapy. A novel iNKT cell agonist, b-mannosylceramide (b-ManCer), induces strong antitumor immunity through a mechanism distinct from that of a-GalCer. The objective of this study was to determine whether b-ManCer induces anergy of
منابع مشابه
β-mannosylceramide activates type I natural killer t cells to induce tumor immunity without inducing long-term functional anergy.
PURPOSE Most studies characterizing antitumor properties of invariant natural killer T (iNKT) cells have used the agonist, α-galactosylceramide (α-GalCer). However, α-GalCer induces strong, long-lasting anergy of iNKT cells, which could be a major detriment for clinical therapy. A novel iNKT cell agonist, β-mannosylceramide (β-ManCer), induces strong antitumor immunity through a mechanism disti...
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